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Calcium carbonate tablets are used as calcium supplement for hypocalcemia patients such as acute and chronic hypoparathyroidism, postmenopausal women, osteoporosis, rickettsia and osteomalacia. In recent years, physicians also used for binding phosphate and maintain calcium balance in patients with chronic renal failure. In year 2016, Calcium carbonate tablets were selected by Bureau of Drug and Narcotic for quality survey. The samples were collected from public hospitals. Total of 40 samples from 9 companies, with 18 registration numbers at strength 350, 600, 625, 835, 1000, 1250, and 1500 mg were evaluated according to United States Pharmacopoeia 39 (USP 39). The tests were composed of identification, content of active ingredient, weight variation and dissolution. Two samples (5%) did not meet the requirement due to dissolution test. The results indicated that most of Calcium carbonate tablets have satisfactory quality. The summary report was published in GREEN BOOK which was distributed to government hospitals to be used for the procurement of drugs.
Keyword : calcium carbonate tablets, quality